Due to the progressive nature of ME and OI, Daan is lying in bed for more than 23 hours a day. His world is small and his life standing still. In addition to the severe fatigue in his body, he suffers from headaches, neck pain, stimuli, poor concentration, tremors, difficulty swallowing, blurred vision, little focus and no energy. Sounds also come in differently and loud noises hurt, he can no longer sit properly without becoming ill and he suffers from Post-Exertional Malaise (PEM). After every physical or cognitive effort, his complaints are worsened which results in him having even more difficulty tolerating stimuli. This deterioration can last for days, weeks or months. He needs the help of his parents in almost every act. All of a sudden, his future looks very different. His physical strength is still decreasing rapidly, the muscle strength in his body is decreasing whilst the neurological complaints are increasing.